搜索肿瘤医学资讯

随着大分子单抗、TKI、ADC等药物的上市，对于曲妥珠单抗治疗失败的HER2阳性晚期乳腺癌患者来说，当前二线治疗方案可选药物众多。但对于中国患者来说，一些药物可及性较差，不能满足患者的治疗需求。本届ASCO大会上，天津医科大学肿瘤医院郝春芳教授团队开展的PROVE研究结果揭晓，该研究探索了吡咯替尼联合长春瑞滨节拍化疗治疗曲妥珠单抗治疗失败的HER2阳性晚期乳腺癌的疗效和安全性（摘要号1034），本文对相关内容进行介绍。

中世纪犹太教首屈一指的哲学家迈蒙尼德提出了至今仍然困惑大多数健康领域工作者的哲学问题——“治病”和“救人”，哪个放在首位？

In this interview， Professor Xu Yingying from the First Affiliated Hospital of China Medical University will talk with Professor Javier Cortes from IOB， Institute of Oncology， Quiron Group， in Madrid & Barcelona， Spain， to share the main design and data of the study， and to discuss the strategy of chemotherapy de-escalation.

Editor’s note: The annual meeting of American Society of Clinical Oncology (ASCO) was held in the form of online conference for the first time， the theme of ASCO 2020 is “Unite and ConDr Liuer: Accelerating Progress Together”. In this ASCO meeting， Latest researh advances in all fields of cancer have been publised and presented， in the aspect of CAR-T treatment， Oral abstract of 8001(ALEXANDER study) became the focus of ASCO， dual-targeting CAR-T (AUTO3) shows significant efficacy and safety in relapsed and refractory Diffuse Large B Cell Lymphoma (r/r-DLBCL). In order to learn more about ALEXANDER study and other related Dr Liuestions about CAR-T， we invited Dr Zhiming Li who is from Sun Yat-sen University Cancer Center as the host of this interview， and first author of ALEXANDER study Dr Osborne made a deep analysis of ALEXANDER study and dual-targeting CAR-T therapy.

At the 2020 ASCO conference， Professor Thomas Powles from Barts Cancer Institute and the London School of Medicine and Dentistry， UK， has reported the JAVELIN Bladder 100 study， which showed that patients with advanced urothelial cancer treated with avilumab as the first-line maintenance therapy followed with chemotherapy could significantly improve OS compared with the control group. In this interview， Professor Yu Wei from the first hospital of Peking University will talk to Professor Powles to share the main results of this study and the immunotherapy strategy for advanced urothelial cancer.

Editor’s note: May 29th， 2020 to 2nd June 2020， the annual meeting of the American Society of Clinical Oncology (ASCO) was held as a virtual meeting online and many important advances were presented at this ASCO. ASCO annual meeting is the largest international academic meeting in the field of cancer. ENDURANCE study is a phase 3 trial that compared triplet regimen of KRd with VRd for the treatment of newly diagnosed multiple myeloma (NDMM). In order to learn more about this study， we invited Professor Hou Jian from Department of Hematology， Renji Hospital Affiliated to Shanghai Jiao tong University， and Professor Shaji Kumar from Hematology Department of Mayo Clinic (first author of ENDURANCE study); the two experts made a comprehensive analysis of ENDURANCE study and MM therapy.

The Annual Meeting of American Society of Clinical Oncology (ASCO) this year was held on-line during 29/5 to 2/6. In the meeting， the Long-term result of trial “MINDACT” was presented by Prof. Fatima Cardoso from Champalimaud Cancer Center of Lisbon， Portugal. As a de-escalation trail， MINDACT investigated the feasibility of using Mammaprint， a genomic test to predict the risk of recurrence of breast cancer patients comparing to clinical pathological factors， which drew a great deal of attention from participants. In this presented conversation， we invited Prof. Cardoso and Prof. Jian Zhang from Cancer Hospital of Fudan University， to in-depth interpret the results of MINDACT， and exhibit the clinical significance of this long term trail to our follower.